Vioxx Library

Does Vioxx cause heart attacks?: A disputed study

Graham, D.J. 2004. Testimony of David J. Graham [before the Senate Finance Committee], MD, MPH, November 18, 2004.

Graham, D.J. 2004. Memo describing the disputed VIOXX study. See especially the Introduction, Discussion, and the paragraph on page 7 entitled "Survey of Controls".

Graham, D.J. et al. 2005. Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study • ARTICLE The Lancet 365: 475-481. This is the published version of the preceding memo.

Does Vioxx cause heart attacks?: A recent metaanalysis

Kearney, et al. 2006. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. British Medical Journal 332: 1302-8.

The Vioxx dispute

Rubin, R. 2004. Scientists says FDA called journal to block Vioxx article. USA Today, 28 November 2004.

Scientific publishing: Peer review and conflict of interest

Van McCrary, S. et al. 2004. A national survey of policies on disclosure of conflicts of interest in biomedical research. New England Journal of Medicine 343: 1621-1626. Angell, M. 2000. Is academic medicine for sale? New England Journal of Medicine 342: 1516-1518.

Anonymous. 2004. New England Journal of Medicine: Disclosure and authorship statement.

Epidemiological studies in general

Reference Guide on Epidemiology. See especially the sections entitled "The types of observational study designs" and "What biases may have contributed?"

A Vioxx reader (mostly for background)

Topol, E. 2004. Failing the Public Health — Rofecoxib, Merck, and the FDA New England Journal of Medicine

Lenzer, J. 2004. Public interest group accuses FDA of trying to discredit whistleblower. British Medical Journal 329: 1255.

Lenzer, J. 2004. FDA is incapable of protecting US 'against another Vioxx'. British Medical Journal

Abbasi, K. 2004. Is drug regulation failing? British Medical Journal

U.S. Senate Finance Committee. 2004. FDA, Merck and Vioxx: Putting Patient Safety First?